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    <link:label id="lab_us-gaap_AmortizationOfFinancingCosts_35419B95CCFE93A7E9D6AC8976EB1069_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCosts_35419B95CCFE93A7E9D6AC8976EB1069" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amortization of Debt Issuance Costs</link:label>
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    <link:label id="lab_us-gaap_DeferredIncomeTaxesAndTaxCredits_1C336BB77C7FF0D3A651AC8976EBA32C_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxesAndTaxCredits_1C336BB77C7FF0D3A651AC8976EBA32C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Deferred Income Taxes and Tax Credits</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_AA0B0FE11FAB720E809DAC8976EBA019" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_AA0B0FE11FAB720E809DAC8976EBA019" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_AA0B0FE11FAB720E809DAC8976EBA019" xlink:type="arc" />
    <link:label id="lab_iclr_IncreaseDecreaseinContractwithCustomerAsset_D1589C35ED86D2532074AC98569AF0FB_negatedLabel_en-US" xlink:label="lab_iclr_IncreaseDecreaseinContractwithCustomerAsset_D1589C35ED86D2532074AC98569AF0FB" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Increase in unbilled revenue</link:label>
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    <link:label id="lab_iclr_IncreaseDecreaseinContractwithCustomerAsset_D1589C35ED86D2532074AC98569AF0FB_documentation_en-US" xlink:label="lab_iclr_IncreaseDecreaseinContractwithCustomerAsset_D1589C35ED86D2532074AC98569AF0FB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Increase (Decrease) in Contract with Customer, Asset</link:label>
    <link:loc xlink:href="iclr-20180630.xsd#iclr_IncreaseDecreaseinContractwithCustomerAsset" xlink:label="loc_iclr_IncreaseDecreaseinContractwithCustomerAsset_D1589C35ED86D2532074AC98569AF0FB" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_iclr_IncreaseDecreaseinContractwithCustomerAsset_D1589C35ED86D2532074AC98569AF0FB" xlink:to="lab_iclr_IncreaseDecreaseinContractwithCustomerAsset_D1589C35ED86D2532074AC98569AF0FB" xlink:type="arc" />
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInOtherReceivables" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_CAD4192BC08BE8BC134AAC8976EC0315" xlink:type="locator" />
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    <link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_92737BD47592F3597147AC8976EC8F60_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_92737BD47592F3597147AC8976EC8F60" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Decrease/(increase) in prepayments and other current assets</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_92737BD47592F3597147AC8976EC8F60_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_92737BD47592F3597147AC8976EC8F60" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Increase (Decrease) in Prepaid Expense and Other Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_92737BD47592F3597147AC8976EC8F60" xlink:type="locator" />
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    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_224C68A2956ADAB5C214AC8976EC4F61_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_224C68A2956ADAB5C214AC8976EC4F61" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Increase (Decrease) in Other Noncurrent Assets</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_224C68A2956ADAB5C214AC8976EC4F61" xlink:type="locator" />
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    <link:label id="lab_iclr_IncreaseDecreaseInContractWithCustomerLiability_EE4A6D72DB4F6AFE32C8AC95C2B3D281_terseLabel_en-US" xlink:label="lab_iclr_IncreaseDecreaseInContractWithCustomerLiability_EE4A6D72DB4F6AFE32C8AC95C2B3D281" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Increase/(decrease) in payments on account</link:label>
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    <link:label id="lab_iclr_IncreaseDecreaseInContractWithCustomerLiability_EE4A6D72DB4F6AFE32C8AC95C2B3D281_documentation_en-US" xlink:label="lab_iclr_IncreaseDecreaseInContractWithCustomerLiability_EE4A6D72DB4F6AFE32C8AC95C2B3D281" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Increase (Decrease) In Contract With Customer Liability</link:label>
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    <link:label id="lab_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_C1759F3A722265A3C8ABAC8974FD9203_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_C1759F3A722265A3C8ABAC8974FD9203" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Purchase of property, plant and equipment</link:label>
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