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<!-- Round: 3e178c8d-0161-41fb-a57d-00d73afc7cc3 -->
<!-- Creation date: 2014-05-12T10:19:15Z -->
<!-- Copyright (c) 2005-2013 R.R. Donnelley & Sons Company All Rights Reserved. -->
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        <link:definition>109 - Disclosure - Goodwill</link:definition>
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        <link:definition>113 - Disclosure - Net income per ordinary share</link:definition>
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        <link:definition>114 - Disclosure - Share-based Awards</link:definition>
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        <link:definition>117 - Disclosure - Business Combinations (Tables)</link:definition>
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        <link:definition>121 - Disclosure - Share-based Awards (Tables)</link:definition>
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        <link:definition>123 - Disclosure - Goodwill (Detail)</link:definition>
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        <link:definition>124 - Disclosure - Business Combinations - Additional Information (Detail)</link:definition>
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        <link:definition>125 - Disclosure - Summary of Estimates of Fair Values of Assets Acquired and Liabilities Assumed of Clinical Trial Services Division of Cross Country Healthcare, Inc. (Detail)</link:definition>
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        <link:definition>126 - Disclosure - Recognized Restructuring and Other Items, Net (Detail)</link:definition>
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        <link:definition>129 - Disclosure - Income Taxes Recognized During Period (Detail)</link:definition>
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        <link:definition>131 - Disclosure - Reconciliation of Number of Shares Used in Computation of Basic and Diluted Net Income Per Ordinary Share (Detail)</link:definition>
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        <link:definition>132 - Disclosure - Share-based Awards - Additional Information (Detail)</link:definition>
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        <link:definition>138 - Disclosure - Distribution of Net Revenue by Geographical Area (Detail)</link:definition>
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        <link:definition>139 - Disclosure - Distribution of Income from Operations, including Restructuring and Other Items, by Geographical Area (Detail)</link:definition>
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        <link:definition>140 - Disclosure - Distribution of Income from Operations, excluding Restructuring and Other Items, by Geographical Area (Detail)</link:definition>
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        <link:definition>141 - Disclosure - Distribution of Property, Plant and Equipment, Net, by Geographical Area (Detail)</link:definition>
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  <element name="BusinessAcquisitionPurchasePriceAllocationWorkingCapital" id="iclr_BusinessAcquisitionPurchasePriceAllocationWorkingCapital" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedUnbilledRevenue" id="iclr_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedUnbilledRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="CapitalGovernmentGrantsNoncurrent" id="iclr_CapitalGovernmentGrantsNoncurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="CapitalRedemptionReserve" id="iclr_CapitalRedemptionReserve" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="CapitalRedemptionReserveMember" id="iclr_CapitalRedemptionReserveMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ClinicalTrialServicesMember" id="iclr_ClinicalTrialServicesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="CompensationRelatedCostsShareBasedPaymentsDisclosureLineItems" id="iclr_CompensationRelatedCostsShareBasedPaymentsDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="CompensationRelatedCostsShareBasedPaymentsDisclosureTable" id="iclr_CompensationRelatedCostsShareBasedPaymentsDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
  <element name="DocumentAndEntityInformationAbstract" id="iclr_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="EmployeeMember" id="iclr_EmployeeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="EmployeeStockPlanTwentyZeroEightPlanMember" id="iclr_EmployeeStockPlanTwentyZeroEightPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="EmployeeStockPlanTwentyZeroThreePlanMember" id="iclr_EmployeeStockPlanTwentyZeroThreePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="FirstQuarterTwentyThirteenRestructuringPlanMember" id="iclr_FirstQuarterTwentyThirteenRestructuringPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="IncomeTaxExpenseBenefitBeforeNonrecurringCharges" id="iclr_IncomeTaxExpenseBenefitBeforeNonrecurringCharges" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="IncomeTaxExpenseBenefitForNonrecurringChargesTax" id="iclr_IncomeTaxExpenseBenefitForNonrecurringChargesTax" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="IncreaseDecreaseInPrepaidExpenseAndOtherCurrentAssets" id="iclr_IncreaseDecreaseInPrepaidExpenseAndOtherCurrentAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="OfficeConsolidationsMember" id="iclr_OfficeConsolidationsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="OperatingIncomeByGeographyTableTextBlock" id="iclr_OperatingIncomeByGeographyTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="OperatingIncomeLossBeforeRestructuringCharges" id="iclr_OperatingIncomeLossBeforeRestructuringCharges" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxLongTermFunding" id="iclr_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxLongTermFunding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentLongTermFundingTax" id="iclr_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentLongTermFundingTax" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="OtherCountriesMember" id="iclr_OtherCountriesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="PerformanceShareUnitMember" id="iclr_PerformanceShareUnitMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ReconciliationOfProvisionOfIncomeTaxesLineItems" id="iclr_ReconciliationOfProvisionOfIncomeTaxesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ReconciliationOfProvisionOfIncomeTaxesTable" id="iclr_ReconciliationOfProvisionOfIncomeTaxesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
  <element name="RecoveryOfAmortizationOfGovernmentGrants" id="iclr_RecoveryOfAmortizationOfGovernmentGrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RestOfEuropeMember" id="iclr_RestOfEuropeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RestrictedStockUnitsTwentyThirteenMember" id="iclr_RestrictedStockUnitsTwentyThirteenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RestrictedStockUnitsTwentyZeroEightMember" id="iclr_RestrictedStockUnitsTwentyZeroEightMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RestructuringAndOtherCharges" id="iclr_RestructuringAndOtherCharges" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RestructuringChargeNet" id="iclr_RestructuringChargeNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RestructuringChargesResidualBalanceFromPriorPeriod" id="iclr_RestructuringChargesResidualBalanceFromPriorPeriod" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RestructuringChargesTableTextBlock" id="iclr_RestructuringChargesTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ScheduleOfDepreciationAndAmortizationExpenseByGeographicalAreaTableTextBlock" id="iclr_ScheduleOfDepreciationAndAmortizationExpenseByGeographicalAreaTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ScheduleOfNonCashStockCompensationExpenseTableTextBlock" id="iclr_ScheduleOfNonCashStockCompensationExpenseTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ScheduleOfShareBasedCompensationRestrictedStockUnitsPerformanceStockUnitsAwardActivityTableTextBlock" id="iclr_ScheduleOfShareBasedCompensationRestrictedStockUnitsPerformanceStockUnitsAwardActivityTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ScheduleOfWeightedAverageNumberOfDilutedSharesOutstandingLineItems" id="iclr_ScheduleOfWeightedAverageNumberOfDilutedSharesOutstandingLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ScheduleOfWeightedAverageNumberOfDilutedSharesOutstandingTable" id="iclr_ScheduleOfWeightedAverageNumberOfDilutedSharesOutstandingTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
  <element name="SecondQuarterTwentyThirteenRestructuringPlanMember" id="iclr_SecondQuarterTwentyThirteenRestructuringPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SegmentReportingDisclosureLineItems" id="iclr_SegmentReportingDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SegmentReportingDisclosureTable" id="iclr_SegmentReportingDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardForfeitedInPeriodWeightedAverageGrantDateFairValue" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardForfeitedInPeriodWeightedAverageGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsForfeitedInPeriodWeightedAverageExercisePrice" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsForfeitedInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsGrantedInPeriodWeightedAverageExercisePrice" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsGrantedInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsOutstandingExercisePriceAbstract" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsOutstandingExercisePriceAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsOutstandingWeightedAverageExercisePrice" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsVestedInPeriodWeightedAverageExercisePrice" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonvestedOptionsVestedInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionGrantsGrantDateFairValue" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionGrantsGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageGrantDateFairValue" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodWeightedAverageGrantDateFairValue" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodWeightedAverageGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageOptionPrice" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageOptionPrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageGrantDateFairValue" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsWeightedAverageGrantDateFairValueAbstract" id="iclr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsWeightedAverageGrantDateFairValueAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsExpectedVestingPeriod" id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsExpectedVestingPeriod" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="UnrecognizedTaxBenefitsCurrentYearTaxPositions" id="iclr_UnrecognizedTaxBenefitsCurrentYearTaxPositions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="WorkforceReductionMember" id="iclr_WorkforceReductionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>





