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  <xs:element id="iclr_LongTermDebtCurrentMaturitiesGross" abstract="false" name="LongTermDebtCurrentMaturitiesGross" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_ShceduleOfOperatingIncomeByGeographyTableTextBlock" abstract="false" name="ShceduleOfOperatingIncomeByGeographyTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="iclr_LongTermDebtMaturityYearFourAndThereafter" abstract="false" name="LongTermDebtMaturityYearFourAndThereafter" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_ChangeInAdvancePaymentsNettedAgainstUnbilledContractsReceivablePercent" abstract="false" name="ChangeInAdvancePaymentsNettedAgainstUnbilledContractsReceivablePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iclr_StockRepurchaseProgramAuthorizedPercentage" abstract="false" name="StockRepurchaseProgramAuthorizedPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="iclr_RestOfEuropeMember" abstract="true" name="RestOfEuropeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iclr_IncreaseDecreaseInContractWithCustomerAssetGrossCurrent" abstract="false" name="IncreaseDecreaseInContractWithCustomerAssetGrossCurrent" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_RestOfWorldMember" abstract="true" name="RestOfWorldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iclr_Clients610Member" abstract="true" name="Clients610Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="iclr_NonExecutiveDirectorMember" abstract="true" name="NonExecutiveDirectorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
