
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
   <link:roleRef roleURI="http://www.iconplc.com/2010-12-31/role/StatementOfShareholdersEquity" xlink:href="iclr-20101231.xsd#statementOfShareholdersEquity" xlink:type="simple"/>
   <link:roleRef roleURI="http://www.iconplc.com/2010-12-31/role/StatementOfCashFlowsIndirect" xlink:href="iclr-20101231.xsd#statementOfCashFlowsIndirect" xlink:type="simple"/>
   <link:roleRef roleURI="http://www.iconplc.com/2010-12-31/role/StatementOfIncome" xlink:href="iclr-20101231.xsd#statementOfIncome" xlink:type="simple"/>
   <link:roleRef roleURI="http://www.iconplc.com/2010-12-31/role/StatementOfFinancialPositionClassified" xlink:href="iclr-20101231.xsd#statementOfFinancialPositionClassified" xlink:type="simple"/>
   <link:calculationLink xlink:role="http://www.iconplc.com/2010-12-31/role/StatementOfFinancialPositionClassified" xlink:type="extended">
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="lbl_AssetsCurrent" xlink:type="locator"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_Assets" xlink:label="lbl_Assets" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_Assets" xlink:to="lbl_AssetsCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="lbl_PropertyPlantAndEquipmentNet" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_Assets" xlink:to="lbl_PropertyPlantAndEquipmentNet" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_Goodwill" xlink:label="lbl_Goodwill" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_Assets" xlink:to="lbl_Goodwill" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="lbl_OtherAssetsNoncurrent" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_Assets" xlink:to="lbl_OtherAssetsNoncurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncomeTaxesReceivableNoncurrent" xlink:label="lbl_IncomeTaxesReceivableNoncurrent" xlink:type="locator"/>
      <link:calculationArc order="5.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_Assets" xlink:to="lbl_IncomeTaxesReceivableNoncurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DeferredTaxAssetsNetNoncurrent" xlink:label="lbl_DeferredTaxAssetsNetNoncurrent" xlink:type="locator"/>
      <link:calculationArc order="6.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_Assets" xlink:to="lbl_DeferredTaxAssetsNetNoncurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="lbl_FiniteLivedIntangibleAssetsNet" xlink:type="locator"/>
      <link:calculationArc order="7.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_Assets" xlink:to="lbl_FiniteLivedIntangibleAssetsNet" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="lbl_CashAndCashEquivalentsAtCarryingValue" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_CashAndCashEquivalentsAtCarryingValue" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:label="lbl_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="lbl_AccountsReceivableNetCurrent" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_AccountsReceivableNetCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_UnbilledContractsReceivable" xlink:label="lbl_UnbilledContractsReceivable" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_UnbilledContractsReceivable" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NontradeReceivablesCurrent" xlink:label="lbl_NontradeReceivablesCurrent" xlink:type="locator"/>
      <link:calculationArc order="5.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_NontradeReceivablesCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DeferredTaxAssetsNetCurrent" xlink:label="lbl_DeferredTaxAssetsNetCurrent" xlink:type="locator"/>
      <link:calculationArc order="6.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_DeferredTaxAssetsNetCurrent" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_PrepaidExpensesAndOtherCurrentAssets" xlink:label="lbl_PrepaidExpensesAndOtherCurrentAssets" xlink:type="locator"/>
      <link:calculationArc order="7.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_PrepaidExpensesAndOtherCurrentAssets" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncomeTaxesReceivable" xlink:label="lbl_IncomeTaxesReceivable" xlink:type="locator"/>
      <link:calculationArc order="8.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_AssetsCurrent" xlink:to="lbl_IncomeTaxesReceivable" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="lbl_LiabilitiesCurrent" xlink:type="locator"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="lbl_LiabilitiesAndStockholdersEquity" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesAndStockholdersEquity" xlink:to="lbl_LiabilitiesCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="lbl_OtherLiabilitiesNoncurrent" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesAndStockholdersEquity" xlink:to="lbl_OtherLiabilitiesNoncurrent" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_CapitalGovernmentGrantsNoncurrent" xlink:label="lbl_CapitalGovernmentGrantsNoncurrent" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesAndStockholdersEquity" xlink:to="lbl_CapitalGovernmentGrantsNoncurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AccruedIncomeTaxesNoncurrent" xlink:label="lbl_AccruedIncomeTaxesNoncurrent" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesAndStockholdersEquity" xlink:to="lbl_AccruedIncomeTaxesNoncurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DeferredTaxLiabilitiesNoncurrent" xlink:label="lbl_DeferredTaxLiabilitiesNoncurrent" xlink:type="locator"/>
      <link:calculationArc order="5.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesAndStockholdersEquity" xlink:to="lbl_DeferredTaxLiabilitiesNoncurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="lbl_AccountsPayableCurrent" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesCurrent" xlink:to="lbl_AccountsPayableCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="lbl_DeferredRevenueCurrent" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesCurrent" xlink:to="lbl_DeferredRevenueCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="lbl_OtherLiabilitiesCurrent" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesCurrent" xlink:to="lbl_OtherLiabilitiesCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DeferredTaxLiabilitiesCurrent" xlink:label="lbl_DeferredTaxLiabilitiesCurrent" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesCurrent" xlink:to="lbl_DeferredTaxLiabilitiesCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="lbl_AccruedIncomeTaxesCurrent" xlink:type="locator"/>
      <link:calculationArc order="6.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesCurrent" xlink:to="lbl_AccruedIncomeTaxesCurrent" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="lbl_StockholdersEquity" xlink:type="locator"/>
      <link:calculationArc order="7.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_LiabilitiesAndStockholdersEquity" xlink:to="lbl_StockholdersEquity" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_CommonStockValue" xlink:label="lbl_CommonStockValue" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_StockholdersEquity" xlink:to="lbl_CommonStockValue" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="lbl_AdditionalPaidInCapitalCommonStock" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_StockholdersEquity" xlink:to="lbl_AdditionalPaidInCapitalCommonStock" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="lbl_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_StockholdersEquity" xlink:to="lbl_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="lbl_RetainedEarningsAccumulatedDeficit" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_StockholdersEquity" xlink:to="lbl_RetainedEarningsAccumulatedDeficit" xlink:type="arc"/>
   </link:calculationLink>
   <link:calculationLink xlink:role="http://www.iconplc.com/2010-12-31/role/StatementOfIncome" xlink:type="extended">
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="lbl_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:type="locator"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="lbl_NetIncomeLoss" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetIncomeLoss" xlink:to="lbl_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="lbl_IncomeTaxExpenseBenefit" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetIncomeLoss" xlink:to="lbl_IncomeTaxExpenseBenefit" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="lbl_OperatingIncomeLoss" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:to="lbl_OperatingIncomeLoss" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="lbl_InvestmentIncomeInterest" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:to="lbl_InvestmentIncomeInterest" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_InterestExpenseDebt" xlink:label="lbl_InterestExpenseDebt" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:to="lbl_InterestExpenseDebt" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="lbl_SalesRevenueNet" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_OperatingIncomeLoss" xlink:to="lbl_SalesRevenueNet" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_CostsAndExpenses" xlink:label="lbl_CostsAndExpenses" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_OperatingIncomeLoss" xlink:to="lbl_CostsAndExpenses" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_ContractsRevenue" xlink:label="lbl_ContractsRevenue" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_SalesRevenueNet" xlink:to="lbl_ContractsRevenue" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_CostOfReimbursableExpense" xlink:label="lbl_CostOfReimbursableExpense" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_SalesRevenueNet" xlink:to="lbl_CostOfReimbursableExpense" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="lbl_CostOfGoodsAndServicesSold" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CostsAndExpenses" xlink:to="lbl_CostOfGoodsAndServicesSold" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="lbl_SellingGeneralAndAdministrativeExpense" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CostsAndExpenses" xlink:to="lbl_SellingGeneralAndAdministrativeExpense" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="lbl_DepreciationAndAmortization" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CostsAndExpenses" xlink:to="lbl_DepreciationAndAmortization" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_ResearchAndDevelopmentIncentivesAndRestructuringCharges" xlink:label="lbl_ResearchAndDevelopmentIncentivesAndRestructuringCharges" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CostsAndExpenses" xlink:to="lbl_ResearchAndDevelopmentIncentivesAndRestructuringCharges" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="lbl_NetIncomeLossAttributableToNoncontrollingInterest" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetIncomeLoss" xlink:to="lbl_NetIncomeLossAttributableToNoncontrollingInterest" xlink:type="arc"/>
   </link:calculationLink>
   <link:calculationLink xlink:role="http://www.iconplc.com/2010-12-31/role/StatementOfCashFlowsIndirect" xlink:type="extended">
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:type="locator"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="lbl_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="lbl_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="lbl_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="lbl_NetIncomeLoss" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_NetIncomeLoss" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_AmortizationOfGovernmentGrants" xlink:label="lbl_AmortizationOfGovernmentGrants" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_AmortizationOfGovernmentGrants" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="lbl_ShareBasedCompensation" xlink:type="locator"/>
      <link:calculationArc order="5.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_ShareBasedCompensation" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="lbl_DeferredIncomeTaxExpenseBenefit" xlink:type="locator"/>
      <link:calculationArc order="6.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_DeferredIncomeTaxExpenseBenefit" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="lbl_NetIncomeLossAttributableToNoncontrollingInterest" xlink:type="locator"/>
      <link:calculationArc order="7.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_NetIncomeLossAttributableToNoncontrollingInterest" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="lbl_DepreciationAndAmortization" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_DepreciationAndAmortization" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_CashAcquiredFromAcquisition" xlink:label="lbl_CashAcquiredFromAcquisition" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:to="lbl_CashAcquiredFromAcquisition" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_ProceedsFromGrants" xlink:label="lbl_ProceedsFromGrants" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:to="lbl_ProceedsFromGrants" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:label="lbl_ProceedsFromSaleOfShortTermInvestments" xlink:type="locator"/>
      <link:calculationArc order="5.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:to="lbl_ProceedsFromSaleOfShortTermInvestments" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="lbl_PaymentsToAcquirePropertyPlantAndEquipment" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:to="lbl_PaymentsToAcquirePropertyPlantAndEquipment" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments" xlink:label="lbl_PaymentsToAcquireShortTermInvestments" xlink:type="locator"/>
      <link:calculationArc order="6.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:to="lbl_PaymentsToAcquireShortTermInvestments" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_ProceedsFromLinesOfCredit" xlink:label="lbl_ProceedsFromLinesOfCredit" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:to="lbl_ProceedsFromLinesOfCredit" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="lbl_ProceedsFromStockOptionsExercised" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:to="lbl_ProceedsFromStockOptionsExercised" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities" xlink:label="lbl_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities" xlink:type="locator"/>
      <link:calculationArc order="5.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:to="lbl_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_ProceedsFromPaymentsForOtherFinancingActivitiesAndRepaymentsOfLongTermCapitalLeaseObligations" xlink:label="lbl_ProceedsFromPaymentsForOtherFinancingActivitiesAndRepaymentsOfLongTermCapitalLeaseObligations" xlink:type="locator"/>
      <link:calculationArc order="7.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:to="lbl_ProceedsFromPaymentsForOtherFinancingActivitiesAndRepaymentsOfLongTermCapitalLeaseObligations" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="lbl_PaymentsOfStockIssuanceCosts" xlink:type="locator"/>
      <link:calculationArc order="4.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:to="lbl_PaymentsOfStockIssuanceCosts" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="lbl_IncreaseDecreaseInDeferredRevenue" xlink:type="locator"/>
      <link:calculationArc order="13.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInDeferredRevenue" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_IncreaseDecreaseInOtherCurrentLiabilities" xlink:label="lbl_IncreaseDecreaseInOtherCurrentLiabilities" xlink:type="locator"/>
      <link:calculationArc order="14.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInOtherCurrentLiabilities" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable" xlink:label="lbl_IncreaseDecreaseInAccruedIncomeTaxesPayable" xlink:type="locator"/>
      <link:calculationArc order="15.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInAccruedIncomeTaxesPayable" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="lbl_IncreaseDecreaseInAccountsPayable" xlink:type="locator"/>
      <link:calculationArc order="16.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInAccountsPayable" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="lbl_IncreaseDecreaseInAccountsReceivable" xlink:type="locator"/>
      <link:calculationArc order="8.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInAccountsReceivable" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncreaseDecreaseInUnbilledReceivables" xlink:label="lbl_IncreaseDecreaseInUnbilledReceivables" xlink:type="locator"/>
      <link:calculationArc order="9.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInUnbilledReceivables" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_IncreaseDecreaseInOtherReceivables" xlink:label="lbl_IncreaseDecreaseInOtherReceivables" xlink:type="locator"/>
      <link:calculationArc order="10.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInOtherReceivables" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="lbl_RepaymentsOfLinesOfCredit" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInFinancingActivities" xlink:to="lbl_RepaymentsOfLinesOfCredit" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_IncreaseDecreaseInOtherNoncurrentLiabilities" xlink:label="lbl_IncreaseDecreaseInOtherNoncurrentLiabilities" xlink:type="locator"/>
      <link:calculationArc order="14.5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInOtherNoncurrentLiabilities" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment" xlink:label="lbl_GainLossOnSaleOfPropertyPlantEquipment" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_GainLossOnSaleOfPropertyPlantEquipment" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_IncreaseDecreaseInPrepaymentsAndOtherCurrentAssets" xlink:label="lbl_IncreaseDecreaseInPrepaymentsAndOtherCurrentAssets" xlink:type="locator"/>
      <link:calculationArc order="11.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInPrepaymentsAndOtherCurrentAssets" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_IncreaseDecreaseInOtherNoncurrentAssets" xlink:label="lbl_IncreaseDecreaseInOtherNoncurrentAssets" xlink:type="locator"/>
      <link:calculationArc order="12.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInOperatingActivities" xlink:to="lbl_IncreaseDecreaseInOtherNoncurrentAssets" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_PaymentsToAcquireBusinessesAndAcquisitionCosts" xlink:label="lbl_PaymentsToAcquireBusinessesAndAcquisitionCosts" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_NetCashProvidedByUsedInInvestingActivities" xlink:to="lbl_PaymentsToAcquireBusinessesAndAcquisitionCosts" xlink:type="arc"/>
   </link:calculationLink>
   <link:calculationLink xlink:role="http://www.iconplc.com/2010-12-31/role/StatementOfShareholdersEquity" xlink:type="extended">
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="lbl_NetIncomeLoss" xlink:type="locator"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="lbl_ComprehensiveIncomeNetOfTax" xlink:type="locator"/>
      <link:calculationArc order="1.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_ComprehensiveIncomeNetOfTax" xlink:to="lbl_NetIncomeLoss" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecrease" xlink:label="lbl_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecrease" xlink:type="locator"/>
      <link:calculationArc order="2.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_ComprehensiveIncomeNetOfTax" xlink:to="lbl_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecrease" xlink:type="arc"/>
      <link:loc xlink:href="http://taxonomies.xbrl.us/us-gaap/2009/elts/us-gaap-2009-01-31.xsd#us-gaap_OtherComprehensiveIncomeReclassificationOfDefinedBenefitPlansNetGainLossRecognizedInNetPeriodicBenefitCostNetOfTax" xlink:label="lbl_OtherComprehensiveIncomeReclassificationOfDefinedBenefitPlansNetGainLossRecognizedInNetPeriodicBenefitCostNetOfTax" xlink:type="locator"/>
      <link:calculationArc order="3.0" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_ComprehensiveIncomeNetOfTax" xlink:to="lbl_OtherComprehensiveIncomeReclassificationOfDefinedBenefitPlansNetGainLossRecognizedInNetPeriodicBenefitCostNetOfTax" xlink:type="arc"/>
      <link:loc xlink:href="iclr-20101231.xsd#iclr_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxLongTermFunding" xlink:label="lbl_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxLongTermFunding" xlink:type="locator"/>
      <link:calculationArc order="2.5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="lbl_ComprehensiveIncomeNetOfTax" xlink:to="lbl_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxLongTermFunding" xlink:type="arc"/>
   </link:calculationLink>
</link:linkbase>





